Mahatma Phule Krishi Vidyapeeth, Rahuri, established in 1968 and functioning now with 15 constituent colleges, 27 Research Stations and 63 affiliated private colleges is addressing the agricultural education, research and extension needs of 10 districts of Western Maharashtra. The university over the period has developed more than 310 improved crop varieties, hybrids, agricultural implements and came up with recommendations and contingency plans for the betterment of agriculture in its jurisdiction. At this juncture, with emergence of new challenges arised due to climate change and changing needs, the University has to restructure itself and attain leadership through dynamic transformation in Agricultural Education, Research and create an impact through its Extension Activities on the livelihood of the stakeholders. Agricultural Education is of prime importance to the university and sustaining the academic programme equating to new education policy is a major challenge. A relook at the university academic programme aligning with new education policy and focusing on overall development of the student with improved exposure, skill and knowledge is of utmost importance for the sustenance of technology led agriculture. The micro environment of education should be made conducive to create a pool of innovators, researchers, agripreneurs, and value chain developers for tomorrow. The next major thrust is on research programme of the university keeping in view the challenges of climate change,sustenance of crop yields and soil health and natural resource conservation with diversification approach. The research focus shall be on crop improvement for climate resilience, bio-fortification to ensure nutritional security, agricultural mechanization with automation, SMART agriculture and changing from production approach to value chain development approach. Research on adaptation and mitigation measures, input use efficiency and ecosystem approach for sustainable agriculture shall also attract equal importance. Extension is the backbone of the agricultural research and education system that creates an effective linkage with the stakeholders for mutual benefit. The extension system should be strengthened with the advances in Information Technology to improve the reach of the technologies to the farmers effectively without much time lag. The University is taking the lead in bringing together other like-minded institutions working in the field viz., NGO’s, FPO’s and work towards transformation of the farmers into entrepreneurs and creating an enterprising agriculture. Startup ecosystem is being developed to impart skill development and agri-entrepreneurship useful for rural youths, farmers and students. With the rejuvenation of the three pillars of the university viz. Education, Research and Extension along with the stakeholders, as the fourth pillar, let us lay a strong foundation for the agricultural development in the region as well as in the Maharashtra State.